Apparatus to investigate the interaction between the particles and the lung

摘要

To provide a structure and method for investigating the dissolution of particles in the air blood barrier of the respiratory tract. The perfusion chamber device for simulating the interaction particles carried to the air / blood barrier of the airway (203) has been to deliver and accept the flow of perfusion fluid (101), a barrier to one side including coated with (204) layer, and is adapted to interact with the particles semipermeable membrane and (205), sheet-like organ having a first surface by spraying the particles and (202). To simulate the dissolution particles at the air / blood barrier when the perfusion liquid flows along the (205) film (101) in the perfusion chamber (203), and to fluid contact with the perfusion fluid film (205) While placed in, and arranged so as to contact the barrier layer film (205) to (204) sheet of the first organ (202). By providing a flow of the perfusion fluid along the film, the natural action of the air / blood barrier is simulated more accurately.