Dihydropyridine derivatives for the treatment of cancer or precancerous symptoms and other symptoms

摘要

The use of dihydropyridine-5-phosphonic acid cyclic propylene ester derivatives of formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of said compound or prodrug in the treatment of cancers, pre-cancerous conditions and other conditions is disclosed, wherein each of R1-R8 are the same or different, are hydrogen or C1-C6 alkyl; one of X1 and X2 is nitro while the other is hydrogen; each of Y1 and Y2 may be the same or different, is phenyl which may be substituted by chlorine, fluorine or alkoxy; and m and n are integers from 0-4, a prodrug thereof, or a pharmaceutically acceptable salt thereof.