HEPATOPATHY MODEL ANIMAL AND METHOD FOR SCREENING DRUG OR FOOD MATERIAL TO AMELIORATE OR PREVENT HEPATOPATHY BY USING THE ANIMAL

摘要

PROBLEM TO BE SOLVED: To provide a new hepatopathy model animal constructing a simple, accurate and useful in vivo evaluation system, available at a remarkably reduced cost and causing little ethical problems compared with conventional techniques, a method for preparing the animal, and a method for exhaustively/screeningly searching a hepatopathy treating agent and a food material having hepatic function improving or hepatopathy preventing function for mammals such as human, in contrast with conventional model animals practically unable to perform such searching, even by using the in vivo evaluation system to use the hepatopathy model animal.;SOLUTION: The hepatopathy model animal is a larva of a holometabolous insect having treatable damage on its fat body and/or intestinal canal by administration of a compound. There is further provided a screening method for the drug or food material effective for ameliorating or preventing hepatopathy of mammals by using the hepatopathy model animal.;COPYRIGHT: (C)2010,JPO&INPIT