Covalent bonding method of the two molecules with the reverse electron requirement Diels-Alder reaction

摘要

The present invention, A method for binding the two molecules by (DARinv) Diels-Alder reaction with reverse electron request, said method comprising the reaction of (b) and the following (a). As (a) diene component, -COOR -C (O) NR ₂ -CX ₃ (X is halogen) - Halogen -CN_SO 3 -R or ₂ -R -SO_(In the formula, H, an alkyl group, an aryl group, R is a heterocyclic group, an alkyl group, OH group, SH group, a halogen, an aryl group, these heterocyclic group as necessary -PR 2, The. which may be substituted nitro, carboxamide, an amino group) - In [the heterocyclic ring, having the N atom of one, two or three, and is substituted with phosphonic carboxyl group of one, or a sulfonic acid group, or S atoms O atoms, the size of the ring at least heterocyclic is a 6-membered ring or a 5-membered ring Saga,] Having on the ring an electron-withdrawing group is one or more selected from, or triazine as the diene component, tetrazine. The isolated olefins in the hydrocarbon chain branched or straight chain which may contain hetero atoms as required in (b) as dienophile component, or triple bonds, or a double and isolated in the (hetero) carbocycle double or triple bonds sex.