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Use of cathelicidin antibacterial protein (hCAP18) as anticancer agent
Use of cathelicidin antibacterial protein (hCAP18) as anticancer agent
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机译:Cathelicidin抗菌蛋白(hCAP18)作为抗癌剂的用途
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摘要
The present invention provides the use of a polypeptide comprising an amino acid sequence according to SEQ ID NO: 1 (corresponding to the N-terminal 25 amino acid fragment of the human antimicrobial protein, LL-37) or a biologically active fragment, variant, fusion or derivative thereof, in the preparation of a medicament for the treatment of cancer. In particular, the inventions provides the use such polypeptides, or a fragment, variant, fusion or derivative thereof, to inhibit the proliferation and/or metastasis of cancer cells, such as breast cancer cells. The invention further comprises methods for the treatment of cancer in a patient.
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机译:本发明提供了包含根据SEQ ID NO:1的氨基酸序列(对应于人抗微生物蛋白的N-末端25个氨基酸片段,LL-37)或生物活性片段,变体的多肽的用途,在制备用于治疗癌症的药物中的融合或衍生物。特别地,本发明提供了这样的多肽或其片段,变体,融合或衍生物用于抑制癌细胞如乳腺癌细胞的增殖和/或转移的用途。本发明进一步包括用于治疗患者癌症的方法。
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