Undercarboxylated / uncarboxylated osteocalcin increases beta cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases body fat mass

摘要

The present invention relates to methods and compositions for treating and diagnosing disorders related to energy metabolism and the OST-PTP signaling pathway involving gamma-carboxylase, osteocalcin and adiponectin. Such disorders include, but are not limited to, metabolic syndrome, glucose intolerance, diabetes types 1 and 2, atherosclerosis and obesity.