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Method for suppressing malignancy of tumor cells using microenvironment of human embryonic stem cells
Method for suppressing malignancy of tumor cells using microenvironment of human embryonic stem cells
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机译:利用人类胚胎干细胞微环境抑制肿瘤细胞恶性的方法
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摘要
The invention provides compositions comprising one or more isolated factors from a microenvironment of human embryonic stem cells (hESCs), including, but not limited to, Lefty and inhibitors of Nodal. The invention also provides methods of utilizing factors derived from human embryonic stem cells (hESC) and their microenvironment to treat and prevent tumor formation and progression and to inhibit tumor cell aggressiveness. The invention further provides methods of inhibiting tumor cell growth and/or treating aggressive tumors in a mammal comprising administering to the mammal, having at least one tumor cell present in its body, an effective amount of an inhibitor of Nodal activity.
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