The individual generating the omnipotent sex cell which

摘要

PROBLEM TO BE SOLVED: To provide a model animal having only disordered synapse maturation but having normal other drebrin-associated functions and a method for screening a candidate treating agent of the synapse maturation disorder by using the model animal.;SOLUTION: The drebrin A knockout mouse is prepared by isolating a mouse-derived drebrin gene, preparing a targeting vector inserted with loxP sequences so as to nip a drebrin A specific exon 11A, performing a homologous recombination for ES (embryonic stem) cells, transducing the recombinant ES cells into individuals, obtaining descendants F1 having the recombinant gene by using chimera individuals having the body cells derived from the ES cells in a high ratio as parents and mating the individual F1 with a mouse expressing Cre gene to obtain individual bodies losing the drebrin A specific exon 11A nipped by 2 loxP sequences, and mating the female and male of the individuals.;COPYRIGHT: (C)2006,JPO&NCIPI