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7-Hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives having preventive and therapeutic effects on degenerative and inflammatory diseases
7-Hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives having preventive and therapeutic effects on degenerative and inflammatory diseases
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机译:对变性和炎性疾病具有预防和治疗作用的7-羟基-6-甲氧基-1,2,3,4-四氢异喹啉衍生物
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摘要
Provided are 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives and synthesis methods thereof. The compounds significantly inhibit the production of nitrogen monoxide (NO) and superoxide in an activated microglial cell and expressions of TNF-, IL-1 inducive NO synthase and cyclooxygenase-2 genes. They also prevent NF-kB shift to a nucleus, decrease reactive oxygen species (ROS), inhibit expression of GTP cyclohydrolase I gene and over-production of tetrahydrobiopterin (BH4), and protect dopaminergic neurons from injury due to activated microglial cells. Consequently, the compounds are effective in treating inflammatory and neurodegenerative diseases.
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