Infertility treatment agent, the screening method of in vitro fertilization accelerator and infertility treatment agent

摘要

PPROBLEM TO BE SOLVED: To obtain a fertility medicine, to obtain an external fertilization promoter, and to provide a method for screening the fertility medicine. PSOLUTION: The fertility medicine contains a kemokine inhibitor (the antagonist, antisense nucleic acid, siRNA, kemokine expression inhibitor, or the like, of kemokine or a kemokine receptor) or its salt as an active ingredient. The external fertilization promoter contains the kemokine inhibitor (the antagonist, antisense nucleic acid, siRNA, kemokine expression inhibitor or the like of kemokine or the kemokine receptor) or its salt as an active ingredient. The method for screening the fertility medicine comprises discriminating the presence or absence of the effect of a substance to be tested to the interaction of the kemokine with the kemokine receptor and then selecting a sample for inhibiting the interaction. According to the present invention, the interaction of the kemokine receptor with the ligand of the receptor (chemokine) is inhibited to achieve the normalization of a cumulus cell expansion, the increase in the number of ovulations, and the improvement in fertility. PCOPYRIGHT: (C)2005,JPO&NCIPI