Orthogonality method in order to remove infection characteristic spongy brain symptom factor from the raw body fluids

摘要

The hemoglobin and making the raw body fluids contact which at least include one pathogenic factor with the first filter, and it forms the first filtrate; Making the first filtrate contact with the nano- filtration device, and it forms the second filtrate; Making the second filtrate contact with the chromatography material, and the cutoff which it liquates it is isolated; Making the cutoff contact which it liquates with the hydrophobic solvent, and it forms hydrophobia and hydrophilic phase; And hydrophilic phase it is isolated, the raw body fluids include the process which includes the component of the interest object below approximately 65kDa here, method. The high-molecular quantitative component and making the raw body fluids contact which at least include one pathogenic factor with the first filter, and it forms the first filtrate; Making the first filtrate contact with the hydrophilic membrane, and it forms the second filtrate; Making the second filtrate contact with the chromatography material, and the cutoff which it liquates it is isolated; Making the cutoff contact which it liquates with the hydrophobic solvent, and it forms hydrophobia and hydrophilic phase; And hydrophilic phase it is isolated, the high-molecular quantitative component includes the process which possesses the molecular weight which is larger than approximately 65kDa here, method. The hemoglobin and the raw body fluids which at least include one pathogenic factor, are offered to two filtration processes at least, the process which makes the quantity of the pathogenic factor decrease which assembles in the raw body fluids and with that, is included, method. The person and/or the process which removes the infection characteristic spongy brain symptom factor in the hemoglobin solution of the animal beginning is included the hemoglobin solution, by offering to the orthogonality separated methodology which includes plural filtration processes, method. Selective figure Figure 1