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Nitrogen oxide releasing prodrug of diaryl 2- (5H) -furanone acting as cyclooxygenase-2 inhibitor
Nitrogen oxide releasing prodrug of diaryl 2- (5H) -furanone acting as cyclooxygenase-2 inhibitor
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机译:二芳基2-(5H)-呋喃酮作为环氧合酶2抑制剂的氮氧化物释放前药
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摘要
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.
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