Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist

摘要

Agents for treating and preventing pain comprise gabapentin or pregabalin or their salts and a N-type calcium channel antagonist or its salt. ACTIVITY : Analgesic. In the formalin induced pain model in SD rats oral administration of N-{3-[4-(5H-benzo[a,d][7]anulen-5-ylidene)-1-piperazinyl]-3-oxopropyl}-2,2-dimethylpropanamide (Ia) at 3 mg/kg, gabapentin at 100 mg/kg and a combination of (Ia) at 3 mg/kg and gabapentin at 100 mg/kg reduced flinching over 60 minutes by 38, 47 and 68 % respectively. MECHANISM OF ACTION : N-Type Calcium Channel Antagonist.