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Method of manufacturing artificial polyclonal immune globulin, as well as, manufacturing method of immune globulin preparations
Method of manufacturing artificial polyclonal immune globulin, as well as, manufacturing method of immune globulin preparations
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机译:人工多克隆免疫球蛋白的制造方法以及免疫球蛋白制剂的制造方法
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摘要
PROBLEM TO BE SOLVED: To provide a method for producing a polyclonal immunoglobulin according to a recombinant DNA technique adaptable to production of an immunoglobulin pharmaceutical preparation.;SOLUTION: A plurality of species of genes encoding a polypeptide containing mutually different immunoglobulin variable regions are isolated. The resultant gene mixture is brought into contact with a vector and integrated to prepare a plurality of species of recombinant vectors corresponding to the various immunoglobulin variable regions and prepare a recombinant vector mixture. The resultant recombinant vector mixture is then brought into contact with a suitable host cell and transduced to prepare a plurality of species of recombinants corresponding to the various immunoglobulin variable regions and prepare a recombinant mixture. The obtained recombinant mixture is finally mixed and cultured to express a plurality of species of polypeptides corresponding to the various immunoglobulin variable regions in the recombinants. A polypeptide mixture thereof is prepared to produce the artificial polyclonal immunoglobulin.;COPYRIGHT: (C)2006,JPO&NCIPI
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