Orally disintegrating tablets and bitterness-suppressing preparations containing risperidone

摘要

The present invention provides risperidone orally disintegrating tablets and bitterness-suppressing preparations. A powder containing risperidone, crystalline cellulose, inorganic excipient, carmellose and a lubricant of 0.8% by weight or less, preferably 0.5% by weight or less, more preferably 0.1% by weight or less per tablet. It has been found that an orally disintegrating tablet exhibiting good disintegration and ensuring tablet hardness can be obtained by compression molding. Further, a powder obtained by granulating an excipient and / or a disintegrant with a solution in which a bitterness-suppressing base is dissolved and / or suspended and risperidone having a water solubility (20 ° C.) of 1 g / mL or less is dissolved or suspended. -If it was a granule preparation or a tablet obtained by tableting the powder / granule preparation, the bitter taste of risperidone could be suppressed.