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MEDICAL DEVICES HAVING POLYMERIC NANOPOROUS COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY AND A NONPOLYMERIC MACROPOROUS PROTECTIVE LAYER
MEDICAL DEVICES HAVING POLYMERIC NANOPOROUS COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY AND A NONPOLYMERIC MACROPOROUS PROTECTIVE LAYER
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机译:具有用于控制治疗剂输送的聚合物纳米孔涂层的医疗设备和非聚合物大孔保护层
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摘要
An implantable or insertable medical device is provided which contains the following: (a) a substrate, (b) a therapeutic agent-containable region disposed over the substrate, (c) a nanoporous polymeric layer disposed over the therapeutic agent-containable region and (d) a macroporous non-polymeric layer disposed over the nanoporous polymeric layer. The nanoporous polymeric layer largely regulates transport of species between the therapeutic agent-containable region and the exterior of the device. The macroporous non-polymeric layer has a larger pore size than the nanoporous polymeric layer and largely serves to isolate the polymeric material from surrounding tissue during in-situ delivery of the therapeutic agents.
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