Multifunctional Device For Diagnostics and Method For Testing Biological Objects

摘要

A multifunctional device for measuring fluorescence, luminescence and light transmission for diagnostics. A sample carrier is designed in the form of a biochip, cell, pan or microplate. The device comprises a first and second group of screens mounted behind the rear surface of a sample solid carrier. Light sources of the sample are provided with light-absorbing elements for suppressing light reflected from the front surface of the sample carrier and from screen surfaces. Screen holders allow for alternatively mounting light reflective/retroreflective screens to maximize fluorescent or luminescent signal. A diffusing screen measures light transmission through the sample. Light-absorbing screens behind the rear surface of the sample and light-absorbing elements on light sources from the sample's top surface, increase signal-to-noise ratio. Said device permits measuring signals on biochip surfaces and in solutions during hybridization or amplification reactions. The device and diagnostic method are suitable for mass screening of biological material samples.