首页> 外国专利> IN VITRO METHODS FOR EVALUATING THE IN VIVO EFFECTIVENESS OF DOSAGE FORMS OF MICROPARTICULATE OR NANOPARTICULATE ACTIVE AGENT COMPOSITIONS

IN VITRO METHODS FOR EVALUATING THE IN VIVO EFFECTIVENESS OF DOSAGE FORMS OF MICROPARTICULATE OR NANOPARTICULATE ACTIVE AGENT COMPOSITIONS

机译：评估微颗粒或纳米颗粒活性剂成分剂量形式的体内功效的体外方法

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摘要

Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.

机译：公开了用于评价水溶性差的活性剂的剂型在体内的再分散性的体外方法。该方法利用代表体内人类生理状况的培养基。

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公开/公告号US2010178648A1

专利类型
公开/公告日2010-07-15

原文格式PDF
申请/专利权人 EUGENE R. COOPER;JOHN A. BULLOCK;JOHN R. CHIPPARI;JOHN L. SCHAEFER;RAKESH A. PATEL;RAJEEV JAIN;JOOST STRASTERS;NIELS P. RYDE;STEPHEN B. RUDDY;
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申请/专利号US20100729018
发明设计人 JOHN R. CHIPPARI;JOOST STRASTERS;STEPHEN B. RUDDY;RAJEEV JAIN;JOHN A. BULLOCK;JOHN L. SCHAEFER;RAKESH A. PATEL;NIELS P. RYDE;EUGENE R. COOPER;
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申请日2010-03-22
分类号C12Q1/00;
国家 US
入库时间 2022-08-21 18:55:40

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1. Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet:In vitro evaluation and in vivo pharmacokinetics study [J] . Guangjing Li, Yongjun Wang, Hongming Chen, 亚洲药物制剂科学(英文) . 2015,第002期

2. Application of RP-HPLC method in dissolution testing and statistical evaluation by NASSAM for simultaneous estimation of tertiary combined dosages forms [J] . Yogesh Upadhyay, Nitin Sharma, G.S. Sarma, 药物分析学报（英文） . 2015,第005期

3. Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: in vitro and in vivo evaluation in healthy volunteers. [J] . Xu X, Sun M, Zhi F, International Journal of Pharmaceutics . 2006,第1a2期

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9. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

1. Design and Development of an iin Vitro/iAssay for Evaluation of Solid Vaginal Dosage Forms [J] . Jyoti Gupta ,Jason Qihai Tao ,Sanjay Garg . 药理与制药（英文） . 2011,第4期

2. In Vivo Evaluation of Functionalized Biomimetic Hydroxyapatite for Local Delivery of Active Agents [J] . Johan Forsgren ,Ulrika Brohede ,Sonya Piskounova . 生物材料与纳米技术（英文） . 2011,第2期

3. Evaluation of the Permeation and Penetration of Two Formulations of Terbinafine Chlorhydrate Incorporated in Liposomes (Cream 1) vs. a Conventional Formulation (Cream 1), in an iin Vitro-ex Vivo/iModel [J] . Sanabria Kinski ,Annunziato Maria Antonieta ,Chacon Nicolas . 生物科学与医学（英文） . 2019,第8期

4. 壳聚糖纳米颗粒的制备及其体内、体外质粒转染研究 [C] . 张昊 ,李淑锋 ,东南大学基础医学院 . 2006世界华人医药生物技术研讨会 . 2006

5. 银纳米颗粒对B16黑色素瘤的体外和体内抗肿瘤活性的研究 [A] . 高宏坤 . 2020