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Method and Compositions for Stimulation of an Immune Response to gp100 using a Xenogeneic gp100 Antigen
Method and Compositions for Stimulation of an Immune Response to gp100 using a Xenogeneic gp100 Antigen
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机译:使用异种gp100抗原刺激对gp100的免疫应答的方法和组合物
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摘要
Tolerance of the immune system for endogenous gp100 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed gp100 antigen. For example, mouse gp100, or antigenically-effective portions thereof, can be used to stimulate an immune response to the corresponding differentiation antigen in a human subject. Administration of xenogeneic antigens in accordance with the invention results in an effective immunity against gp100 expressed by the cancer in the treated individual, thus providing a therapeutic approach to the treatment of cancers expressing gp100, such as melanoma.
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