TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS

摘要

This invention concerns a compound of formula; ;a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents phenyl, pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R¹ represents hydrogen; aryl; formyl; C_1-6alkylcarbonyl; C_1-6alkyl; C_1-6alkyloxycarbonyl; C_1-6alkyl substituted with formyl, C_1-6alkylcarbonyl, C_1-6alkyloxycarbonyl or C_1-6alkylcarbonyloxy; X represents a direct bond; —(CH₂)_n3— or —(CH₂)_n4—X_1a—X_1b—; R² represents an optionally substituted cyclic system; provided that N,3-diphenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine is not included; their use, pharmaceutical compositions comprising them and processes for their preparation.