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Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses
Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses
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机译:针对突变体P53共同表位的人类合成单链抗体及其用途
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摘要
Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
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