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SURFACE-ENHANCED RAMAN SCATTERING (SERS) BASED NANOPARTICLE COMPOSITES
SURFACE-ENHANCED RAMAN SCATTERING (SERS) BASED NANOPARTICLE COMPOSITES
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机译:基于表面增强拉曼散射(SERS)的纳米颗粒复合材料
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摘要
Nanoparticle composites and method of use thereof for simultaneously sensing and probing a biological system, comprising providing a nanoparticle composite comprising a nanoparticle comprising a core and a shell; a first ligand bound to the nanoparticle, said first ligand capable of sensing pH; a second ligand bound to the nanoparticle, said second ligand distinct from said first ligand and capable of binding to a target; and bringing the nanoparticle composite into contact with the biological system to produce a first and a second pH-dependent signal; and analyzing the first or the second signal by means of surface-enhanced Raman spectroscopy.
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