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Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to MHC class I molecules
Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to MHC class I molecules
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机译:选择与MHC I类分子结合后出现在癌细胞表面的候选肽的方法
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摘要
An objective of the present invention is to provide methods for selecting candidate peptides presented on the surface of cancer cells following binding to MHC class I molecules, wherein the peptides are involved in the stimulation of T cell immunity (cellular immunity). The present inventors discovered a new principle of MHC I-mediated antigen presentation in which a T cell antigen epitope is more efficiently presented on MHC I molecules when it is positioned at the N-terminal side than when positioned at the C-terminal side.
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