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Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same

机译:用于透皮或透粘膜给药的佐剂和含有该佐剂的药物制剂

摘要

It is intended to provide a low molecular weight adjuvant which can be administered safely without inducing skin irritation or the like by transdermal or transmucosal administration and is for enhancing immunogenicity of an antigen efficiently. It can be achieved by an immunostimulant adjuvant containing at least one substance selected from the group consisting of aliphatic alcohols, free fatty acids and fatty acid derivatives but does not contain a substance represented by the following formula.; ;(In the formula, R3 and R4 may be combined to form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.)
机译:本发明旨在提供一种低分子量佐剂,其可以通过经皮或透粘膜给药安全地给药而不会引起皮肤刺激等,并且可以有效地增强抗原的免疫原性。通过包含至少一种选自脂族醇,游离脂肪酸和脂肪酸衍生物的物质但不包含下式表示的物质的免疫刺激佐剂可以实现。 ;(式中,R 3 和R 4 可以结合形成一个环,R 1 和R 2 独立表示具有1至16个碳原子的烷基侧链。)

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