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Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor
Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor
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机译:细胞外信号调节激酶停靠域的抑制剂及其用途
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摘要
Provided herein are compounds and methods of using compounds that selectively inhibit binding to one or more docking domain regions of an extracellular signal-recognition kinase to inhibit in a cell having an extracellular signal-regulated kinase activity. Such methods may be used to inhibit cell proliferation of a neoplastic cell, to treat a cancer and further may be used in conjunction with administration of an anticancer drug at a reduced dosage to treat a cancer with a concomitant reduction in toxicity to an individual receiving the treatment. Also provided is a method to design and screen for compounds to inhibit binding within the extracellular signal-regulated kinase docking domain region, using at least in part computer-aided drug design modeling.
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