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Chiral separation, characterization and biological action of optically active isomers of digoxin
Chiral separation, characterization and biological action of optically active isomers of digoxin
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机译:地高辛旋光异构体的手性分离,表征及生物学作用
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摘要
Disclosed herein is the method for separation of enantiomers or isomers of digoxin. These isomers are to be used-in the treatment of heart failure without adverse or unneeded cardiac actions in humans. Additionally what is claimed is an isolate with less or no cardiac contractile effect but with AV node slowing such that the composition would be an effective therapy for the control of the ventricular response in atrial fibrillation. Also disclosed are methods for assaying these isomeric compounds present in biological fluids to enable the separation of pharmacologic actions.
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