首页>
外国专利>
Chimeric osteogenic factor containing proteins capable of increased nuclear localization and methods of use thereof
Chimeric osteogenic factor containing proteins capable of increased nuclear localization and methods of use thereof
展开▼
机译:能够增加核定位的包含嵌合成骨因子的蛋白质及其使用方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compositions comprising osteogenic factors fused with membrane transduction domains of viral proteins are provided. Also provided are methods of expression and use of such compositions. Further, the methods of making such compositions are also provided. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter and optionally a membrane transduction domain of a viral protein. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Methods for treating disc disease associated with trauma or disc degeneration are also described.
展开▼