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Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy
Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy
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机译:使用选择性标记通过核磁共振波谱检测和表征分子相互作用
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摘要
Methods of detecting interactions of a putative ligand with a selectively labeled target molecule, methods of screening for compounds which bind to a selectively labeled target molecule, methods for calculating the dissociation constant of a ligand that binds to a selectively labeled target molecule, and methods to determine the specific amino acids of a target molecule affected by the binding of a ligand, as well as compounds identified by these screening methods, are provided.
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