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Method for predicting effectiveness of chemotherapy using anticancer agent

机译:用抗癌药预测化疗效果的方法

摘要

The present invention provides a method for predicting an effectiveness of chemotherapy using an anticancer agent with high probability. The effectiveness is predicted based on a comparison of a parameter relating to CDK and/or CDK inhibitor in a tumor cell specimen obtained from a patient, with a corresponding threshold value to the parameter. The patient to be subjected this sensitivity prediction test of an anticancer agent is administered with the anticancer agent prior to removal of the tumor cell. The threshold is predetermined based on data of correlation between the selected parameter and anticancer agent therapy results obtained from a number of patients actually performed the therapy. Accordingly, the predicting method can provide information useful for determining whether to perform the chemotherapy to individual patients.
机译:本发明提供了以高概率预测使用抗癌剂的化学疗法的有效性的方法。基于从患者获得的肿瘤细胞样本中与CDK和/或CDK抑制剂有关的参数与该参数的对应阈值的比较来预测有效性。在去除肿瘤细胞之前,将要进行抗癌药敏感性预测测试的患者与抗癌药一起给药。该阈值是根据所选参数和从许多实际进行过治疗的患者获得的抗癌药治疗结果之间的相关性数据预先确定的。因此,该预测方法可以提供对于确定是否对个别患者进行化学疗法有用的信息。

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