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Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
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机译:用于植入式医疗设备的具有活性剂的聚合物的受控温度混合和模塑的方法和系统
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摘要
A method and system for making a composition for use in manufacturing an implantable medical device, such as a drug-eluting and/or delivery stent, is described. The method includes introducing a polymer, active agent, and a solvent into a mixing apparatus such as an extruder. The polymer, active agent, and solvent may be mixed in the apparatus to form a homogeneous or substantially homogeneous polymer mixture. The method may further include controlling a temperature of the polymer mixture in at least a portion of the apparatus. In an embodiment, the polymer mixture may be used as a coating for an implantable medical device, or fabricating an implantable medical device. The invention also includes a composition formed by the method described above.
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