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Cystatin-based peptide tags for the expression and purification of bioactive peptides
Cystatin-based peptide tags for the expression and purification of bioactive peptides
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机译:基于胱抑素的肽标签,用于表达和纯化生物活性肽
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摘要
Cystatin-based peptide tags, referred to here as inclusion body tags (IBTs), are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag.
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