5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC.

摘要

Disclosed are compounds of formula (I); ;wherein R¹ is C_1-6alkyl, halo or haloC_1-6alkyl; R² is hydrogen or C_1-6alkyl; is a single or double bond; each R³ and R⁴, which may be the same or different, are hydrogen, C_1-6alkyl or haloC_1-6alkyl; wherein i) when is a double bond p and q are 1, and ii) when is a single bond, p and q are 2, and one of R³ and one of R⁴, together with their interconnecting atoms, forms a cyclopropane ring which may be substituted by one or two halo or methyl groups, which groups may be the same or different; X is CH or N; when present each R⁵, which may be the same or different, is C_1-6alkyl or halo; or two R⁵ groups may join to form a bridge, which bridge contains one or two atoms; n is 0, 1, 2 or 3; when present each R⁶ which may be the same or different, is C_1-6alkyl or halo; and m is 0, 1, 2 or 3.