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Transgenic nonhuman mammal representing the pathologic conditions of human rheumatoid arthritis
Transgenic nonhuman mammal representing the pathologic conditions of human rheumatoid arthritis
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机译:代表人类类风湿关节炎病理状况的转基因非人类哺乳动物
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摘要
It is intended to provide a transgenic nonhuman mammal well representing the pathologic conditions of human rheumatoid arthritis. A transgenic nonhuman mammal is obtained by transferring a foreign DNA, wherein a DNA selected from the group consisting of an MHC class II transcriptional activator gene, the activity domain of an MHC class II transcriptional activator gene and a variant of an MHC class II transcriptional activator gene is provided under the control of a type II collagen promoter, into a cell at the early stage of development.
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