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Deletion forms of IGE-dependent histamine releasing factor having histamine releasing activity, HRF-binding peptides and the uses thereof
Deletion forms of IGE-dependent histamine releasing factor having histamine releasing activity, HRF-binding peptides and the uses thereof
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机译:具有组胺释放活性的IGE依赖性组胺释放因子,HRF结合肽的缺失形式及其用途
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摘要
The present invention relates to IgE-dependent histamine releasing factor (HRF) and HRF-binding peptides, more precisely, deletion forms of HRF which are able to be formed as dimers containing amino acid sequence represented by SEQ ID NO:3, genes encoding thereof and novel HRF-binding peptides having an activity of inhibiting HRF. The deletion forms of HRF which are able to be formed as dimers of the present invention induces intracellular secretion of histamine and IL-8, making an excellent candidate for a drug for inhibiting allergic reaction triggered by HRF and a kit for detecting HRF in serum of an allergy patient. In addition, novel HFR-binding peptides of the present invention bind to HRF to inhibit the actions of HFR, so they can be effectively used for the prevention and the treatment of allergic diseases of animals including asthma and rhinitis or malaria.
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机译:本发明涉及IgE依赖性组胺释放因子(HRF)和HRF结合肽,更确切地说,是HRF的缺失形式,其能够形成为包含SEQ ID NO:3所示氨基酸序列的二聚体,其编码基因和具有抑制HRF活性的新型HRF结合肽。能够作为本发明的二聚体形成的HRF的缺失形式诱导组胺和IL-8的细胞内分泌,从而成为抑制由HRF触发的变态反应的药物和检测血清中HRF的试剂盒的极好的候选者。过敏患者。另外,本发明的新型HFR结合肽与HRF结合以抑制HFR的作用,因此它们可以有效地用于预防和治疗动物的过敏性疾病,包括哮喘和鼻炎或疟疾。
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