Total synthesis of galanthamine, analogues and derivatives thereof

摘要

The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R₁=a hydrogen atom, R₂=a hydroxy group, R₁ and R₂ together form ═O, R₃, R₄, and R₅ independently=a hydrogen atom, a hydroxy group or a (C₁-C₂)alkoxy group, R₆═H, (C₁-C₁₂)alkyl, (CH₂)_nNR₇R₈, or —(CH₂)_nN⁺R₇R₈R₉ where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO₂, or —NR₆ group where R₆ is as defined above or is an amine protecting group.