4.4 - disusutituidas piperidines, use of the compound in the production of a Medicament, Pharmaceutical Product based compound and a method of Disease Prevention

摘要

These compounds are useful as Drugs, in particular, as renin inhibitors in the Prevention of cardiovascular diseases, cerebrovascular diseases, hypertension, renal failure, and glaucoma, restenosis.Claim 1: a compound of the General formula (1) or one of its Salts, preferably one of its Salts are acceptable for pharmaceutical use, where R2 is piridilo is replaced with 1 - 3 radical selected from the group consisting of Independent Way: alcanoiloxi C1 C1 - alkyl - 6 - 6, Quenilo C2 - 6 - 6, alqueniloxi C2, C1 C2 alqueniloxi - 6 - alkoxy alkyl - 6, 6 - alkoxy - C1, C1 6-alkoxy C1 - 6C1 - alkoxy 6-alkoxy C1 C1 - 6 6 - alkoxy -, alkoxy C1 - 6 - alkoxy - C1 - 6 - alkoxy - C1 - 6 - 6 - alkoxy alkyl C1, C1 - 6 - alkoxy - C1 - 6 - 6 - alkoxy alkyl C1, C1 - 6 - alkoxy alkyl C1 - 6 C1 - 6 - 6 - - i'll take it alquilamino C1 C1 - 6, 6 - alkoxy - alquilsulfanilo C1 C1 - 6, 6 - alquilsulfanilo C1 C1 - alkoxy alkyl C1 - 6 - 6, 6 - alcoxicarbonilo C1, AI - i'll take it coxicarboniioxi C1 C1 - 6 - 6, 6 - alquilsulfanilo alkyl C1, C1 - 6Alquilsulfanilo C1 - 6 - alkoxy - 6 alquilsulfanilo C1, C1 - 6 - aicoxi C1 - 6 - 6 alquilsulfanilo alquiio C1, C1 - 6 - 6 alquilsulfonilo aiquilo C1, C1 - 6 - alkoxy alkyl C1 C1 - 6 - 6, 6 - alkyl alquilsulfonilo C1 - C2 C1 - 6, - 8 alquinilo C1 -, Amino - n 6 - alkoxy optionally mono - or n, n-di - RENTED C1 - 6 - carbonyl amino - alkyd ILO C1 - 6 optionally mono - or N - n, n-di - RENTED C1 - 6 - alkoxy -, aryl pirrolidinil C0 - 6Heterociclil pirrolidinil C0 - 6 - alkoxy -, ariloxi, aryl alkoxy - C0 - C1 - 6 6 - alkoxy -, aryl aicoxi C0 - C1 - 6 - 6 - aicoxi alquiio C1 - 6, 6 - Carboxy alkyl C1 C1 alkyl, cyano -, cyano -, 6 -, 8 - cicloalquiio C3 aicoxi C0 - 6 - 6 cicioaiquilo aicoxi C1, C3 - 8 - 6 - aicoxi aicoxi C0 - C1 - 6 - i'll take it cicloaiquilo C1 - C3 - 6, - 8 - 6 - aicoxi C0 I'll take it cicloalquiio C1 - C3 - 6, - 8 alquilamino C0 - C1 - 6 6 - alkyl, alkyl carbonyl heterociclil - C1 - 6Heterociclil alkyl sulfanyl heterociclil C1 - 6 - alkoxy alkyl - C1 - 6 - 6 - alkoxy heterociclil C1 and C0 - C1 - 6 6 - alkyl substituents; and, in addition to the above, may also be substituted with a maximum of 2 halogens, where the maximum total number of substituents in the radical of piridilo r 2 is 3.