Methods to manage N - (t-butyl isoxixasol 5 - 3 - yl) - n '- (4 - (2 - (7 - 4 - il - ethoxy) imidazo (2,1-b) (1.3) benzothiazole - 2 - il) phenyl) urea for treating a proliferative disease and Pharmaceutical composition

摘要

ILO Convention No. 1: a method of dealing with proliferative diseases in mammals, including the application of formula compounds (1) or salt or solution acceptable to drugs to mammals with or suspected of having proliferative diseases, In this case, the effective amount of treatment is at least 12 mg per day, the method required by any one of ILO Convention No. 10: 1-9 requirements, in which the diffuse disease is cancer. Requirement 11: method of requirement 10,where cancer is a leukemia. Claim 22: The method of any one of claims 1 to 21, further comprising administering to the subject a therapeutically effective amount of a second therapeutic agent. Claim 23: The method of claim 22, wherein the second therapeutic agent is an anticancer agent. Claim 24: The method of claim 23, wherein the anticancer agent is selected from the group consisting of adriamycin, busulfan, cytarabine, cyclophosphamide, dexamethasone, fludarabine, fluorouracil, hydroxyurea, interferons, oblimersen, platinum derivatives, taxol,Topotecano and vinclistina Complaint No. 25: method of complaint No. 23, in which the antibody positive person is the F3 inhibitor selected from PKC 412, mln 578, CEP-701, CT 53518, ct-53608, ct-52923, d-64406, d-65476, agl-2033, ag1295, ag1296, kn-1022, pkc-412, SU5416, SU5614, SU11248, l-00021649 and chi-258. Item 26: any method required in Items 1 to 25 also includes a diagnostic step to determine if there is an active variant FL3. Requirement 28: method of requirement 10, cancer is bladder cancer, breast cancer, cervical cancer, CNS cancer,Colon cancer, esofago cancer, head cancer and cervical cancer, liver cancer, lung cancer, nasofargeo cancer, neuroendocrine cancer, ovarian cancer, pancreatic cancer, prostate cancer, kidney cancer, salivary adenocarcinoma, small cell lung cancer, skin cancer, gastric cancer Testicular cancer, thyroid cancer, uterine cancer or malignant hematology.