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Oxazolidinone Compounds, its polymorphic forms, processes for preparing such polymorphic forms, Pharmaceutical compositions containing them and Uses Thereof for the treatment of bacterial infections

机译:恶唑烷酮化合物,其多晶型形式,制备这种多晶型形式的方法,包含它们的药物组合物及其在细菌感染治疗中的用途

摘要

This provides a compound of formula (1), in Crystalline form, or any of its enantiomers or mixtures thereof, or pharmaceutically acceptable salts or solvates, for use as a Drug, The Compound of formula (1) is active against human pathogens and Gram - Veterinary Some Gram - positive and negative with a weak Inhibitory activity of monoamine oxidase (MAO).They are useful for the treatment of bacterial infections. This also describes forms of the compound (S) - N - [3 - [4 - (Cyano piperidin - 1 - 3 - fluoro - II) phenyl] - 2 - oxo - 5 - methyl - oxazolidin} acetamide.Claim 1: a compound of formula (1), or any of its enantiomers or mixtures thereof, or pharmaceutically acceptable salts or solvates, characterized in that it is used as a Medicine.Claim 3: a polymorphic form, called a form B of a compound according to claim 1, characterized in that it comprises an x-ray diffractogram Peaks approximately 13.4 6.4; characteristic; and 24.6 degrees two Theta.Claim 1: a polymorphic form, called a compound form, according to claim 1, characterized in that it comprises an x-ray diffractogram Peaks characteristic of Greater Intensity than the rest to approximately 16.6 7.1; and 23.2 degrees two Theta.Claim 1: a polymorphic Form C, called a compound form, according to claim 1, characterized in that it comprises an x-ray diffractogram Peaks approximately 8.8 9.5; characteristic; 14.4; 20.3 23.0 degrees; and 2 Theta.
机译:这提供了结晶形式的式(1)化合物或其任何对映异构体或其混合物,或药学上可接受的盐或溶剂化物,用作药物。式(1)化合物对人病原体和革兰氏有活性-兽用革兰氏菌-阳性和阴性,对单胺氧化酶(MAO)的抑制活性较弱,可用于治疗细菌感染。这也描述了化合物(S)-N-[3-[4-(氰基哌啶-1-3-氟-II)苯基]-2-氧代-5-甲基-恶唑烷酮}乙酰胺的形式。权利要求1:a式(1)的化合物或其任何对映异构体或其混合物,或药学上可接受的盐或溶剂化物,其特征在于,其用作药物。权利要求3:一种多晶型物,称为根据权利要求1的化合物的晶型B 1,特征在于它包括一个X射线衍射图,峰约13.4 6.4;特性; 2.根据权利要求1所述的多晶形式,称为化合物形式,其特征在于,它包括X射线衍射图,其峰强度比其余峰大,约为16.6 7.1;和24.6度为2。 2.根据权利要求1所述的多晶形式C,称为化合物形式,其特征在于,它包括X射线衍射图,峰约8.8至9.5;和23.2度。特性; 14.4; 20.3 23.0度;和2 Theta。

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