Methods and Agents for improving the recognition of tumor cells that Express CD 138

摘要

Item 1: methods to reduce the adhesion of estrogen cells to tumor cells These include: immunococcal management of these tumor cells, effective targeting of these tumor cells, concentration of CD138, to reduce the adhesion of estrogen cells to tumor cells, concentration of CD138, selective management of these tumor cells with other cytotoxic agents. Enough to inhibit, delay and / or prevent the development of tumor cells. Second requirement: the method adopted in accordance with the first requirement,The immune cocci include a ephedrine molecule and a targeting agent, in which case the ephedrine molecule and the targeting agent are connected by a separable ligation. Item 3: Method in accordance with Item 2, in which the detached Federation contains a binary link. Item 4: method consistent with requirement 3, in which the Federation is spp or SPDB. Requirement No. 7: method taken in accordance with requirement No. 6,This method reduces the resistance of cell adhesion to another cytotoxic agent, which is not immune cocci, and fully applies this additional cytotoxic agent to inhibit, delay and / or prevent the development of tumor cells. ILO Convention No. 8: the method specified in Convention No. 7, i.e. this cytotoxic agent is mefalan, vincristina, doxorubicina, dexametasona, cyclophosphamide, etopido, citabina, cisprino, talidomida, predinisona, talidomida, bortezomib, lenalidiomida, sorafenib, romidepsina or a combination thereof. Requirement No. 9: method taken in accordance with requirement No. 7,It's an antibody based cell poison Item 11: method according to Item 1 or 2, in which ejaculation molecule is at least one Medina, taxano or one to cc1065, or similar. Item 12: method according to item 11, in which ejaculation molecule is at least one McDonald's, such as DM1, DM3 or DM4. Item 14: the method adopted according to any one of the requirements of items 1 to 4, in which the target targets of the immunoglobulin include: the amino acid sequence of one or part of the heavy chain of the immunoglobulin,This heavy immunoglobulin chain or part of it is at least 70%,At least 80%.At least 90%.At least 95% or at least 98% of serial identities and ID numbers: 1. Item 17: method according to any one of items 1 to 4 and 7 to 9, the patient is a cancer patient with one of the following cancers: multiple polio, ovarian cancer, renal cancer, gallbladder cancer, breast cancer, prostate cancer, lung cancer, cancer Hodgkin's colon cancer and lymphoma cells, chronic lymphocytic leukemia (CLL), but not Hodgkin's,Acute lymphoblastic leukemia (all)Acute gallbladder leukemia (AML)Colon tissue tumor or colon cancer.