Bicyclic compounds with nitrogen content assets in chronic pain conditions

摘要

The compounds are active in chronic pain conditions of different Origins; they may be used alone or with other drugs. Also included is a process for preparing such compounds and Pharmaceutical compositions suitable for delivery to a patient.Claim 1: compounds of the formula (1) in which the R groups are independently C1 - 6 h, alkyl, aryl, CF3 and CH2, c = o, X is link, c = o, SO2, c = N - CN, M is 0, 1, N is 0 1; is a Heterocyclic Group, or a formula (2) in which R1, R2, R4 and R5 are independently h, h Allogenic, alkyl alkoxy C1 C1 - 6, 6 -, cyano, amino, Hydroxy, aryl, alquiloamino C1 - 6Di (alkyl amino aminoc1 C1 - 6), 6alquilo C1 - alkyl -, 6 - aminoc1 - 6aiquiio, di (alkyl C1 - 6) 6alquilo aminoc1 - Carboxy - or perhaloc1 6alquilo; R3 is perhaloc1 - 6alquilo h, alkyl, halogen, alkoxy C1 C1 - 6, 6 -, cyano, carboxy, hydroxy alquiloamino C1, 6 - di (alkyl, amino, aminoc1 C1 - 6) 6alquilo C1 -, alkyl - 6 - 6alquilo aminoc1 -, or di (alquiio C1 - 6) aminoc1 - 6alquilo; or two adjacent groups chosen from R1,R2, R3, R4, R5, Can form a methylenedioxy group or ethylenedioxy, provided that: (i) when, simultaneously, and X is CH2, is c = o or SO2, M is 1, N is 0 and R1, R2, R4 and R5 are all then R3 is Hydrogen, h, F CL, OCH3, CH3,; (ii) when simultaneously, and X is CH2, is c = 0, month 1, N is 0 OR 1, And R1, R4 and R5 (R1, R2 and R5) are all hydrogens,Then with R3 (R2 or R3 to R4) do not form a methylenedioxy or ethylenedioxy Group; (iii) when simultaneously, and is CH2 and M and N are both 1 - X, then the Group took jointly is not a 4 - or benzoyl benzoyl fluorobencenosulfonil insustituido.