Polisustituidos Derivatives of 2 - aryl - 6 - phenyl imidazo 1,2-a pyridines, Pharmaceutical compositions containing the same, Preparation Process, Intermediates for the synthesis and use in the Treatment or prevention of diseases involving nuclear receptors such as NURR 1

摘要

Claim 1: compounds of the formula (1) wherein R1 represents a phenyl group or a naphthyl Group, these two groups may be optionally substituted with one or more Atoms or groups are chosen independently of each other between the Halogen Atoms or groups, as follows: Rent - 10 haloalquilo C1 C1, C1 - alkoxy - 10, 10, 10 tioalquilo haloalcoxi C1, C1 - 10, - S (o) alkyl C1 - 10- S (or C1) 2 - alkyl - 10, cyano, Nitro, hydroxyl, hidroxialquileno C1 - 10, 10 - nrarb alquileno C1 C1 - alkoxy -, 10 - alquileno C1 - 10 - Oxy, nrarb, conrarb, so2nrarb, nrccord, OC (or C1) nrarb, OCO - alkyl - 10 NRCC (O) ore, nrcso2re, alquileno C1 - aryl - aryl or heteroaryl monocyclic, 10,While the aryl or heteroaryl monocyclic eventually substituted with one or more substituents selected from Halogen, alkyl group C1 - 10 10 -, Halo - alkoxy alkyl C1, C1 -, Halo - C1 - 10 nrarb alkoxy, Nitro, hydroxyl, Oxo, cyano, or OCO - C1 - 10 alkyl; X represents 1 to 4 Substituent S identical or different from each other, selected from Hydrogen, halogen, alkyl of C1 - 10C1 - 10 nrarb, alkoxy, Nitro, cyano, alkyl C1 - 10 May be eventually replaced with one or More groups selected from Halogen, alkoxy C1 - 10 10 -, Halo - alkoxy C1, nrarb or hydroxyl; R represents in position 3, 5, 7 or 8 of imidazo [1,2-c 1 to 4] pyridine substituents identical Or different from one another, chosen from a Halogen, alkyl of C1 - 10 alkyl, Halo - C1 - 10Alkoxy C1 - 10; R2 and R3 represent, independently of one another, a hydrogen Atom, an alkyl group C1 - 10, eventually replaced with a RF Group, an aryl Group, eventually replaced with one or more substituents selected from Halogen, alkyl group C1 - 10 - 10 - C1 alkyl, halo C1, 10 alkoxy -, Halo - alkoxy C1 - 10, nrarb, hydroxylNitro or cyano; R2 and x can form along with the carbon Atoms that are linked to the carbon cycle from 5 to 7 carbon Atoms; R4 represents a hydrogen Atom, an alkyl group C1 - 10, eventually replaced with a RF Group, an aryl Group, eventually replaced with one or Rivers substituents selected from Halogen, alkyl group C1 - 10 10 -, Halo - alkoxy alkyl C1, C1 - 10Halo - C1 - 10 nrarb alkoxy, Nitro, hydroxyl, alkyl, cyano, C1 - 10 - (CO) - conrarb nrccord, OC (,, OR) nrarb, OCO alkyl C1 - 10 NRCC (OR) or aryl aryl ore, being eventually replaced with one or more substituents selected from Halogen an alkyl group C1 -, 10 -, Halo - alkoxy alkyl C1 C1 - 10, 10, Halo - C1 - 10 nrarb alkoxy, Nitro or cyano, hydroxyl, ra and RB are;Independently of one another, a hydrogen Atom, an alkyl group or C1 - 10 - 10 alquileno C1, aryl or aryl; or ra and RB are jointly, with the nitrogen atom of a group which takes them, azetidine, pyrrolidine, piperidine, morpholine, piperazine tiomorfolina azepine,,, homopiperazina. This group eventually substituted with an alkyl group C1 - 10Aryl or aryl alquileno C1 - 10; RC and Rd represent, independently of one another, a hydrogen Atom, an alkyl group or C1 - 10 - 10 alquileno C1, aryl, aryl, or RC and Rd together form a group alquileno C2 - 5; RE represents an alkyl group C1 - aryl - 10 alquileno C1 - 10, aryl or RC and re form Together; S a group alquileno C2 - 5; RF represents a Halogen Atom, an alkoxy Group C1 - 10Halo - C1 hydroxyl alkoxy -, cyano, 10, nrarb, C (o) nrarb, nrccord, OC (OR) nrarb, OCO - C1 - 10 nrccoore alkyl, aryl, so2nrarb, nrcso2re, alquileno C1 - 10, aryl, aryl eventually being replaced with one or more substituents selected from Halogen, an alkyl group C1 - 10 alkyl, Halo - C1 - 10 C1 10 alkoxy -, Halo - C1 - 10 nrarb, alkoxy, Nitro, hydroxyl,Cyano or OCO alkyl C1 - 10; in the form of a base or an Acid Addition Salt.