FUSED bicyclic Compounds, a process for its preparation, The Compound to be used as a Medicament in the treatment and prophylaxis of diseases, a Pharmaceutical Composition and a set comprising separate packages of the compound and an active ingredient of the medication

摘要

These compounds can be used to treat neurodegenerative diseases, bacterial infections, asthma, organ failure, cancer, organ transplant problems, and transplants. Claim 1: a compound, formula (1) is as follows: "refers to a link or a double link, or refers to CRC, CH, or s; V refers to C or N; W refers to N or CR1; RA refers to perfluoralquilo, a, nh-a, NH - (CH2) P-A, het quilo, or X refers to a link, also refers to co-het, Co-N (H) 2-m (a) m, COOA, Co, CS, or X refers to Si, so, s Means C, or s, or Ar or het. RB refers to AR, het2, RC refers to h, asphalt, AR, het; AR refers to single ring or double ring,carbocyclic aromatic having 6 to 14 carbon atoms, which is unsubstituted or monosubstituted, disubstituted or trisubstituted by, Hal, CF3, OCF3, NO2, CN, perfluoroalkyl, A, OH, NH2, COH, CONH2, NHCOA, -NHSO2A , -NHSO2-N (H) 2-m (A) m, N (H) 1-qAqCOA, N (H) 1-qASO2-N (H) 2-m (A) m, N (H) 1- qAqCON (H) 2-m (A) m, COOA, -SO2A, -SO2N (H) 2-m (A) m, -SO2Het, or SO2Het2 or Ar denotes group (2);X denota CO SO CS o un enlace Het denota un anillo heteroc clico monoc clico o bic clico saturado insaturado o arom tico que posee 1 a 4 tomos de NO y 2Fo S que se encuentra no sustituido o monosustituido disustituido o trisustituido por alquilo que posee 1 Alcox, Hal, CF3, ocfj, NO2, CN, pfoil, OA, CH, CONH2, nhoa, nhoa, nhso2-n (H) 2-m (a) m, COA, so2n (H) 2-m (a) m, so2het, so2j with 1 to 8 carbon atoms, wherein the tar group with 1 to 6 carbon atoms, or het2 refers to the following group: (3)M stands for 0, 1 or 2; P stands for 0.1, 2, 3, 4; Q stands for 0 or 1, a is a kind of linear or tar with 1 to 12 C atoms, one or more of the 1 to 7 atoms, preferably h, can be replaced by Hal, AR, het, or6, CN, conr'r '` coor6 or NR', one or more of which takes precedence over 1 to 7 non adjacent CH2 groups and can be replaced by O, NR6 or S. By component - CH = ch-o-c:O refers to the ring armour or ring armour carat with 3-7 ring C atoms; R1, R2, R3 are h, Hal, CF3, tar respectively; or AR, R ',R "refers to h, AR, het or a.r6 is h, i.e. derivatives containing 1 to 12 C atoms and their derivatives, solutions, ceramics, salts and acceptable stereoisomers of agents, including adhesion or linear derivatives of their mixtures in all relationships.