Compositions monovalent Antibody variable domains for Binding to CD28 and Methods of use

摘要

Is associated with a domain of monovalent polypeptide that binds specifically to CD28, as with an antagonist of CD28 antagonist, where the domain of monovalent comprises a polypeptide that binds specifically to CD28. Domains of monovalent polypeptides comprising a simple variable Domain Antibody that binds a monovalent to CD28.A simple variable Domain Antibody is monovalent Binding to CD28 can inhibit the activity of CD28. In One aspect, a single variable domain of anti-cd28 Antibody monovalent comprises or consists of a simple variable Domain Antibody that binds specifically to CD28 antagonist activity, in one aspect, Dying without substantial activity of CD28.In Another aspect, The simple variable domain of anti-cd28 Antibody monovalent is a simple variable domain of Human Antibody.Also includes methods for antagonizing Interactions with CD28 / CD80 and CD86 or in an individual, and Methods for the treatment of diseases or Disorders that involve Interactions with CD28 / CD80 or CD86 and; The Methods include the Administration of a domain variabl Simple and anti-cd28 Antibody monovalent the individual.