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A process for reductively alkylating a glycopeptide antibiotic comprising a saccharide containing one # 4 amine and one or more other amines.
A process for reductively alkylating a glycopeptide antibiotic comprising a saccharide containing one # 4 amine and one or more other amines.
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机译:一种使糖肽抗生素还原烷基化的方法,该糖肽抗生素包含含有一种#4胺和一种或多种其他胺的糖。
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摘要
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.
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