PROCESS FOR INSULATING (ALPHA S, BETA R) -6-BROMO-ALPHA- 2- (DIMETHYLAMINE) ETHYL -2-METHOXY-ALPHA-1- NAPHTHALENYL-BETA-PHENYL-3-QUINOLINAETHANOL, USE OF (11BR) -4-HYDROXIDINAFTE 2,1-D: 1 ', 2'-F 1,3,2 DIOXAFOSFEPIN A AS A RESOLUTION AGENT AND A SALT

摘要

The present invention relates to a process for isolating (244 S, 225 R) -6-bromo- 244 - [2- (dimethylamino) ethyl] -2-methoxy- 244 -1naphthalenyl - 225 -phenyl-3-quinolineethanol from a mixture of 6-bromo- 244- [2- (dimethylamino) ethyl] -2-methoxy-244 -1-naphthalenyl- 225 - stereoisomeric forms phenyl-3-quinoline-ethanol by optical resolution with 4-hydroxydinafto [2,1-d: 1 ', 2'-f] [1,3,2] dioxaphosphepinaquiral 4-oxide or a derivative thereof, in particular 4-oxide of (11Î ± R) -4-hydroxydinephto [2,1-d: 1 ', 2'-f] [1,3,2] dioxaphosphepine as resolving agent.