stable nanoparticulate composition, method for preparing it, use thereof, pharmaceutical composition, use thereof, dosage form, controlled release composition, and use thereof

摘要

STABLE NANOPARTICULATE COMPOSITION, METHOD FOR PREPARING IT, USE OF THE SAME, PHARMACEUTICAL COMPOSITION, USE OF THE SAME, FORM OF DOSAGE, CONTROLLED RELEASE COMPOSITION, AND, USE OF THE SAME. The present invention provides a composition comprising ziprasidone used in the treatment and prevention of schizophrenia and similar psychiatric disorders. In one embodiment, the composition comprises nanoparticulate particles comprising ziprasidone and at least one surface stabilizer. Nanoparticulate particles have an effective average particle size of less than about 2,000 nm. In another embodiment, the composition comprises a modified release composition which upon administration to a patient delivers ziprasidone in a bimodal, multimodal or continuous manner. The invention also relates to dosage forms containing such compositions, and methods for treating and preventing schizophrenia and similar psychiatric disorders.