DERIVATIVES DERIVATIVES AS AN INHIBITORS OF POLO-SIMILAR KINASE APPLIED IN THE TREATMENT OF CANCER

摘要

The compounds of formula (I) are inhibitors of Polo-like kinases (PLKs) and are used in the treatment of cell proliferative diseases, where R and R are hydrogen or optionally substituted (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl or (C — C) cycloalkyl group; R and R 'are independently selected from hydrogen, —CN, hydroxyl, halogen, optionally substituted (C — C) alkyl, (C — C) alkenyl, (C — C) alkynyl or (C — C) cycloalkyl, - NRR or (C — C) alkoxy, where R and R are independently hydrogen or optionally substituted (C — C) alkyl; ring A is an optionally substituted mono- or bicyclic carbocyclic or heterocyclic ring or ring system having up to 12 atoms in the ring; T is a radical of formula R-L-Y, where R is an alpha amino acid or an alpha amino acid ester motif linked to ring A by an R-LY linker as defined in the formula.