LIPOSOMIC READY-MADE FORMS OF BORONIC ACID COMPOUNDS

摘要

A liposome composition is described consisting of liposomes having a peptide boron acid proteosome inhibitor compound enclosed in liposomes. More specifically, liposomes having a compound of formula I or II enclosed in an internal aqueous cavity are charged with a peptide boronic acid compound to form a boronate ester compound within the liposome aqueous cavity. In one embodiment, the liposomes have an outer coating of a hydrophilic polymer chain and are used to treat a solid tumor in a subject.