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INSULIN PRECURSOR WITH MODIFIED C - PEPTIDE FOR THE IMPROVED PRODUCTION OF INSULIN AND INSULIN ANALOGUES
INSULIN PRECURSOR WITH MODIFIED C - PEPTIDE FOR THE IMPROVED PRODUCTION OF INSULIN AND INSULIN ANALOGUES
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机译:改进的C-肽胰岛素前体可改善胰岛素和模拟胰岛素的产生。
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摘要
The invention relates to a precursor of human insulin or of an insulin analog of the formula I:whereinFus is an optionally present fusion portion;B(1-30) is a B chain of human insulin,Y is an amino acid chain which terminates with a basic amino acid at the C terminus;n is from 2 to 50 and indicates the length of the amino acid chain Y; andA(1-21) is an A chain of human insulin,and the A chain and/or the B chain can be modified by amino acid substitution, deletions and/or additions. The present invention also provides DNA coding for the above precursors, preparation and use of the instant precursors and DNA, and a process for preparing human insulin or an insulin analog.
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