POLYPEPTIDE CONJUGATE COMPRISING HUMAN FACTOR VII OR HUMAN FACTOR VIIA LIKE MOLECULES, NUCLEOTIDE SEQUENCE ENCODING THEREFOR, METHOD FOR PRODUCTION THEREOF AND USES THEREOF

摘要

The present invention relates to novel factor VII (FVII) or Factor VIIa (FVIIa) polypeptide conjugates, to their preparation and use in therapy, in particular for the treatment of a variety of coagulation-related disorders. These novel polypeptide conjugates comprise at least one non-polypeptide moiety covalently attached to a polypeptide, wherein the amino acid sequence of the polypeptide differs from that of wild-type FVII or FVIIa in that at least one amino acid residue comprising an attachment group for said non-polypeptide moiety has been introduced or removed. The conjugates of the present invention have one or more improved properties as compared to commercially available rFVIIa, including increased functional in vivo half-life and/or increased plasma half-life, and/or increased bioavailability and/or reduced sensitivity to proteolytic degradation.